In your datadog-agent.yaml, use override.nodeAgent.env to set the DD_IGNORE_AUTOCONF environment variable.
apiVersion: datadoghq.com/v2alpha1
kind: DatadogAgent
metadata:
  name: datadog
spec:
  global:
    credentials:
      apiKey: <DATADOG_API_KEY>
  override:
    nodeAgent:
      containers: 
        agent:
          env:
            - name: DD_IGNORE_AUTOCONF
              value: "redisdb istio"
Then, apply the new configuration.
Add datadog.ignoreAutoconfig to your datadog-values.yaml:
datadog:
 #auto_conf.yaml を無視するインテグレーションの一覧。
  ignoreAutoConfig:
    - redisdb
    - istio
To disable auto configuration integration(s) with the Operator, add the DD_IGNORE_AUTOCONF variable to your datadog-agent.yaml file:
  override:
    nodeAgent:
      containers: 
        agent:
          env:
            - name: DD_IGNORE_AUTOCONF
              value: "redisdb istio"
DaemonSet との自動構成インテグレーションを無効にするには、Agent マニフェストに DD_IGNORE_AUTOCONF 変数を追加します。
DD_IGNORE_AUTOCONF="redisdb istio"